Ral-GTPases: good chances for a long-lasting fame

Ral GTPases regulate biogenesis of cell polarity

Approved: ____________________________________ Thesis Supervisor ____________________________________ Title and Department ____________________________________ Date

Ral GTPases: corrupting the exocyst in cancer cells.

The Ras-like small G-proteins RalA and RalB have achieved some notoriety as components of one of a growing variety of candidate Ras effector pathways. Recent work has demonstrated that Ral GTPase activation is required to support both the initiation and maintenance of tumorigenic transformation of human cells. The mechanistic basis for this support remains to be defined. However, the discovery ...

The Role of Ral GTPases in Human Oncogenic Transformation

The Role of Ral GTPases in Human Oncogenic Transformation by Sameer H. Issaq Department of Pharmacology and Cancer Biology Duke University Date:_______________________ Approved: ___________________________ Christopher Counter, Supervisor ___________________________ Ann Marie Pendergast ___________________________ Christopher Nicchitta ___________________________ Christopher Kontos _____________...

Does premarital cohabitation affect the chances of marriage lasting?

A case of long-lasting misdiagnosed lymphangioma circumscriptum masquerading as dermatitis

Lymphangioma circumscriptum is a rare benign lymphatic malformation, clinically characterized by clusters of translucent vesicles. Uncommon manifestations such as verruciform or zosteriform have also been reported in the literature, yet eczematous-like presentation is extremely rare. The present study describes the case of a young woman with a 16-year history of an exudative eczematous-like pla...